c-myc and c-fos expression in differentiating mouse primary keratinocytes.

  title={c-myc and c-fos expression in differentiating mouse primary keratinocytes.},
  author={Gian Paolo Dotto and Michael Z. Gilman and Mitsuo Maruyama and Robert A Weinberg},
  journal={The EMBO journal},
  volume={5 11},
Expression of the myc and fos genes has been monitored in mouse primary keratinocytes after induction of terminal differentiation by calcium or tetradecanoylphorbol acetate (TPA). myc RNA levels in growing cells are very high and remain elevated even at late times after calcium-induced differentiation. Thus, keratinocytes provide the first example of normal primary cells with persistent c-myc expression irrespective of their proliferative or differentiated state. fos expression is also… CONTINUE READING

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