c-myc activation renders proliferation of Epstein-Barr virus (EBV)-transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1.

@article{Polack1996cmycAR,
  title={c-myc activation renders proliferation of Epstein-Barr virus (EBV)-transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1.},
  author={Axel Polack and Konstanze Hoertnagel and Alexander Pajic and Barbara Christoph and Barbara Baier and Mats Falk and Josef Mautner and Christian Geltinger and Georg W. Bornkamm and Bettina Kempkes},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 19},
  pages={10411-6}
}
Two genetic events contribute to the development of endemic Burkitt lymphoma (BL) infection of B lymphocytes with Epstein-Barr virus (EBV) and the activation of the protooncogene c-myc through chromosomal translocation. The viral genes EBV nuclear antigen 2 (EBNA2) and latent membrane protein 1 (LMP1) are essential for transformation of primary human B cells by EBV in vitro; however, these genes are not expressed in BL cells in vivo. To address the question whether c-myc activation might… CONTINUE READING