c-kit point mutation of extracellular domain in patients with myeloproliferative disorders.

@article{Nakata1995ckitPM,
  title={c-kit point mutation of extracellular domain in patients with myeloproliferative disorders.},
  author={Yuji Nakata and Akiro Kimura and Osamu Katoh and Kuniko Kawaishi and Hideya Hyodo and Koji Abe and Atsushi Kuramoto and Yukio Satow},
  journal={British journal of haematology},
  year={1995},
  volume={91 3},
  pages={661-3}
}
c-kit is a tyrosine kinase receptor whose ligand is stem cell factor (SCF). Gene alteration of the c-kit extracellular domain was analysed by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) in 25 patients with myeloproliferative disorders (MPD). In the N-terminal part of the domain, mobility shifts indicating sequence alteration were detected in three of the patients, two primary myelofibrosis (PMF) and one chronic myelogenous leukaemia (CML). The subsequent… CONTINUE READING
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