c-fos transfection of 3LL tumor cells turns on MHC gene expression and consequently reduces their metastatic competence.

Abstract

Transfection with c-fos genes of cells of a highly metastatic (H-2K- H-2D+) clone, DI22, of the 3LL carcinoma, causes activation of H-2K gene expression. Experiments were carried out to test whether these transfectants exhibit reduced metastatic competence. Studying II mouse c-fos, 6 mouse c-fos and 2 v-fos transfected clones, we observed that clones… (More)

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