c-fos expression interferes with thymus development in transgenic mice.

@article{Rther1988cfosEI,
  title={c-fos expression interferes with thymus development in transgenic mice.},
  author={Ulrich U R{\"u}ther and Werner M{\"u}ller and Tomoki Sumida and Takeshi Tokuhisa and K. Rajewsky and Erwin F Wagner},
  journal={Cell},
  year={1988},
  volume={53 6},
  pages={847-56}
}
To study the function of the proto-oncogene c-fos in hematopoietic tissues, transgenic mice were generated that express c-fos from the H2-Kb promoter in several organs. These H2-c-fos mice have enlarged spleens and hyperplastic thymuses containing an increased number of thymic epithelial cells. The exogenous c-fos expression specifically affects T cell development in the thymus, thereby increasing the fraction of mature thymocytes. Results obtained with bone marrow radiation chimeras suggest… CONTINUE READING
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