c-erbB-2 oncoprotein expression related to chemoradioresistance in esophageal squamous cell carcinoma.

  title={c-erbB-2 oncoprotein expression related to chemoradioresistance in esophageal squamous cell carcinoma.},
  author={Masayuki Akamatsu and Toshiharu Matsumoto and Kuniyuki Oka and Shigetaka Yamasaki and Hiroshi Sonoue and Yoshiaki Kajiyama and Masahiko Tsurumaru and Keisuke Sasai},
  journal={International journal of radiation oncology, biology, physics},
  volume={57 5},
PURPOSE Esophageal carcinoma is a challenging target for radiotherapy. To improve treatment efficacy, an investigation of a predictive factor is desirable. In this study, we evaluated the significance of apoptosis and immunohistochemical staining for p53, Ki-67, c-erbB-2 (HER-2/neu), Ku (p70/p80), and DNA-PKcs for predictive markers of the responsiveness to chemoradiotherapy in esophageal squamous cell carcinoma. MATERIALS AND METHODS This retrospective analysis consisted of 34 patients with… CONTINUE READING
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