c-erbB-2 gene product associates with catenins in human cancer cells.

  title={c-erbB-2 gene product associates with catenins in human cancer cells.},
  author={Atsushi Ochiai and Shingo Akimoto and Yae Kanai and Takeshi Shibata and Takayuki Oyama and Setsuo Hirohashi},
  journal={Biochemical and biophysical research communications},
  volume={205 1},
Phosphorylation of beta-catenin, an intracytoplasmic cadherin-binding protein, causes disruption of the cadherin-mediated cell adhesion system in cancer cells. A 185-kDa phosphorylated protein, identified as the c-erbB-2 gene product, was co-immunoprecipitated with the E-cadherin-catenin complex. Association of the c-erbB-2 gene product with the cadherin-catenin complex was proven to be mediated through beta-catenin and plakoglobin using an in vitro protein-protein precipitation system. These… CONTINUE READING

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