c-erbB-2 (HER-2/neu) protein and drug resistance in breast cancer patients treated with induction chemotherapy.

@article{VargasRoig1999cerbB2P,
  title={c-erbB-2 (HER-2/neu) protein and drug resistance in breast cancer patients treated with induction chemotherapy.},
  author={Laura Mar{\'i}a Vargas-Roig and Francisco E. Gago and Olga M Tello and Mar{\'i}a Teresa Mart{\'i}n de Civetta and Daniel Ram{\'o}n Ciocca},
  journal={International journal of cancer},
  year={1999},
  volume={84 2},
  pages={129-34}
}
Expression of c-erbB-2 protein has been associated with poor prognosis and poor response to chemotherapy in breast cancer patients. In the present prospective study, we have analyzed whether c-erbB-2, p53 and P170 proteins may be determinants of tumor resistance in locally advanced breast cancer patients treated with induction chemotherapy. Biopsies (n = 60) were examined by immuno-histochemistry; in 62% of cases core or incisional biopsies were taken before drug administration, allowing… CONTINUE READING