c-di-GMP (3'-5'-cyclic diguanylic acid) inhibits Staphylococcus aureus cell-cell interactions and biofilm formation.

@article{Karaolis2005cdiGMPD,
  title={c-di-GMP (3'-5'-cyclic diguanylic acid) inhibits Staphylococcus aureus cell-cell interactions and biofilm formation.},
  author={David K. R. Karaolis and Mohammed H. Rashid and Rajanna Chythanya and Wensheng Luo and Mamoru Hyodo and Yoshihiro Hayakawa},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 3},
  pages={1029-38}
}
Staphylococcus aureus is an important pathogen of humans and animals, and antibiotic resistance is a public health concern. Biofilm formation is essential in virulence and pathogenesis, and the ability to resist antibiotic treatment results in difficult-to-treat and persistent infections. As such, novel antimicrobial approaches are of great interest to the scientific, medical, and agriculture communities. We recently proposed that modulating levels of the cyclic dinucleotide signaling molecule… CONTINUE READING

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