c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis.

@article{OppenheimerShaanan2011cdiAMPRD,
  title={c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis.},
  author={Yaara Oppenheimer-Shaanan and Ezequiel Wexselblatt and Jehoshua Katzhendler and Eylon Yavin and Sigal Ben-Yehuda},
  journal={EMBO reports},
  year={2011},
  volume={12 6},
  pages={
          594-601
        }
}
The bacterium Bacillus subtilis produces the DNA integrity scanning protein (DisA), a checkpoint protein that delays sporulation in response to DNA damage. DisA scans the chromosome and pauses at sites of DNA lesions. Structural analysis showed that DisA synthesizes the small molecule cyclic diadenosine monophosphate (c-di-AMP). Here, we demonstrate that the intracellular concentration of c-di-AMP rises markedly at the onset of sporulation in a DisA-dependent manner. Furthermore, exposing… CONTINUE READING

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References

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Sporulation of Bacillus subtilis.

  • Current opinion in microbiology
  • 2004
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