c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance and osmoregulation.

Abstract

Cyclic diadenosine monophosphate (c-di-AMP) is a conserved nucleotide second messenger critical for bacterial growth and resistance to cell wall-active antibiotics. In Listeria monocytogenes, the sole diadenylate cyclase, DacA, is essential in rich, but not synthetic media and ΔdacA mutants are highly sensitive to the β-lactam antibiotic cefuroxime. In this… (More)
DOI: 10.1111/mmi.13622

Topics

Cite this paper

@article{Whiteley2017cdiAMPML, title={c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance and osmoregulation.}, author={Aaron T. Whiteley and Nicholas E Garelis and Bret N. Peterson and Philip H. Choi and Liang Tong and Joshua John Woodward and Daniel A Portnoy}, journal={Molecular microbiology}, year={2017}, volume={104 2}, pages={212-233} }