c-Src regulation of fibroblast growth factor-induced proliferation in murine embryonic fibroblasts.

@article{Kilkenny2003cSrcRO,
  title={c-Src regulation of fibroblast growth factor-induced proliferation in murine embryonic fibroblasts.},
  author={Dawn M Kilkenny and Jonathan V Rocheleau and James P Price and Martha B Reich and Geraldine P. G. Miller},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 19},
  pages={17448-54}
}
Activated fibroblast growth factor receptor 1 (FGFR1) propagates FGF signals through multiple intracellular pathways via intermediates FRS2, PLCgamma, and Ras. Conflicting reports exist concerning the interaction between FGFR1 and Src family kinases. To address the role of c-Src in FGFR1 signaling, we compared proliferative responses of murine embryonic fibroblasts (MEF) deficient in c-Src, Yes, and Fyn to MEF expressing either endogenous levels or overexpressing c-Src. MEF with endogenous c… CONTINUE READING

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