c-Src-null mice exhibit defects in normal mammary gland development and ERα signaling

@article{Kim2005cSrcnullME,
  title={c-Src-null mice exhibit defects in normal mammary gland development and ERα signaling},
  author={Harold Kim and Mike Laing and William Muller},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={5629-5636}
}
The c-Src tyrosine kinase has been implicated to play an integral role in modulating growth factor receptor, integrin and steroid receptor function. One class of steroid receptors that c-Src modulates is the estrogen receptor α (ERα). Although there is strong biochemical evidence supporting a role for c-Src in ERα signaling, the consequence of this association is unclear at the biological level. To explore the significance of c-Src in ERα signaling, we studied the development of various… CONTINUE READING
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