c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs.

@article{OstareckLederer2002cSrcmediatedPO,
  title={c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs.},
  author={Antje Ostareck-Lederer and Dirk H. Ostareck and Christophe Cans and Gitte Neubauer and Karol Bomsztyk and Giulio Superti-Furga and Matthias W. Hentze},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 13},
  pages={4535-43}
}
hnRNPK and hnRNP E1/E2 mediate translational silencing of cellular and viral mRNAs in a differentiation-dependent way by binding to specific regulatory sequences. The translation of 15-lipoxygenase (LOX) mRNA in erythroid precursor cells and of the L2 mRNA of human papilloma virus type 16 (HPV-16) in squamous epithelial cells is silenced when either of these cells is immature and is activated in maturing cells by unknown mechanisms. Here we address the question of how the silenced mRNA can be… CONTINUE READING

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