c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway.

@article{Jin2008cSrcIR,
  title={c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway.},
  author={W. Woody Jin and Chohee Yun and Joon Jeong and Yangho Park and Hy-de Lee and Seong-Jin Kim},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 3},
  pages={
          1391-400
        }
}
TrkC mediates many aspects of growth and development in the central nervous system. TrkC is expressed in a variety of non-neuronal tissues as well as human cancers. TrkC overexpression may drive tumorigenesis, invasion, and metastatic capability in cancer cells. However, relatively little is known about whether TrkC activity is also essential to maintain the malignant properties in human tumors. TrkC expression leads to the constitutive activation of two major effector pathways, namely the Ras… CONTINUE READING

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