c-Src activation plays a role in endothelin-dependent hypertrophy of the cardiac myocyte.

@article{Kovai1998cSrcAP,
  title={c-Src activation plays a role in endothelin-dependent hypertrophy of the cardiac myocyte.},
  author={Branka Jarc Kova{\vc}i{\vc} and Du{\vs}ko Ili{\'c} and Caroline H. Damsky and David G. Gardner},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 52},
  pages={
          35185-93
        }
}
Activation of the atrial natriuretic peptide (ANP) gene is regarded as one of the earliest and most reliable markers of hypertrophy in the ventricular cardiac myocyte. We have examined the role of the nonreceptor tyrosine kinases in the signaling mechanism(s) leading to hypertrophy using human ANP gene promoter activity as a marker. Endothelin (ET), a well known hypertrophic agonist, increased activity of c-Src, c-Yes, and Fyn within minutes and promoted a selective redistribution of each of… CONTINUE READING

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Hypotonic swelling-induced activation of PKN1 mediates cell survival in cardiac myocytes.

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  • 2011
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