c-Src activates endonuclease-mediated mRNA decay.

@article{Peng2007cSrcAE,
  title={c-Src activates endonuclease-mediated mRNA decay.},
  author={Y. Peng and Daniel R Schoenberg},
  journal={Molecular cell},
  year={2007},
  volume={25 5},
  pages={
          779-87
        }
}
  • Y. Peng, Daniel R Schoenberg
  • Published 2007
  • Medicine, Biology
  • Molecular cell
  • The mRNA endonuclease PMR1 initiates mRNA decay by forming a selective complex with its translating substrate mRNA. Previous work showed that the ability of PMR1 to target to polysomes and activate decay depends on the phosphorylation of a tyrosine residue at position 650. The current study shows that c-Src is responsible for activating this mRNA decay pathway. c-Src was recovered with immunoprecipitated PMR1, and it phosphorylates PMR1 in vitro and in vivo. The interaction with c-Src involves… CONTINUE READING
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