c-Ski inhibits the TGF-β signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements


c-Ski inhibits transforming growth factor-β (TGF-β) signaling through interaction with Smad proteins. c-Ski represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. c-Ski also inhibits TGF-β-induced downregulation of genes such as c-myc. However, mechanisms for transcriptional regulation of target… (More)
DOI: 10.1038/sj.onc.1207690


6 Figures and Tables