c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads.

@article{Akiyoshi1999cSkiAA,
  title={c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads.},
  author={Shingo Akiyoshi and Hirofumi Inoue and Jun-ichi Hanai and Kiyoshi Kusanagi and Naoki Nemoto and Kohei Miyazono and Masahiro Kawabata},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 49},
  pages={35269-77}
}
Smads are intracellular signaling mediators of the transforming growth factor-beta (TGF-beta) superfamily that regulates a wide variety of biological processes. Among them, Smads 2 and 3 are activated specifically by TGF-beta. We identified c-Ski as a Smad2 interacting protein. c-Ski is the cellular homologue of the v-ski oncogene product and has been shown to repress transcription by recruiting histone deacetylase (HDAC). Smad2/3 interacts with c-Ski through its C-terminal MH2 domain in a TGF… CONTINUE READING
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