c-Myc stimulates cell invasion by inhibiting FBX8 function.

  title={c-Myc stimulates cell invasion by inhibiting FBX8 function.},
  author={Hyun Jung Cho and Yun Jeong Oh and Junhye Kwon and Jae Young Kwon and Kyung-Soo Kim and HongTae Kim},
  journal={Molecules and cells},
  volume={30 4},
c-Myc is a cellular onco-protein and a transcriptional activator important for cell growth, cell division, and tumorigenesis. Despite all that is known of its function, the mechanism of how c-Myc contributes to tumorigenesis is unclear. To gain insight into the mechanism through which c-Myc protein exerts its oncogenic activity, we performed large-scale, tandem repeat affinity purification and identified the F box only protein 8 (FBX8), an F-box- and Sec7 domain-containing protein, as a novel… CONTINUE READING


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