c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis.

@article{Nanbakhsh2014cMycRE,
  title={c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis.},
  author={Arash Nanbakhsh and C{\'e}cile Pochon and Aude Mallavialle and Sophie Amsellem and Jean Henri Bourhis and Salem Chouaib},
  journal={Blood},
  year={2014},
  volume={123 23},
  pages={3585-95}
}
Cytarabine (cytosine arabinoside) is one of the most effective drugs for the treatment of patients diagnosed with acute myeloid leukemia (AML). Despite its efficiency against AML cells, the emergence of drug resistance due to prolonged chemotherapy in most patients is still a major obstacle. Several studies have shown that drug resistance mechanisms alter the sensitivity of leukemia cells to immune system effector cells. To investigate this phenomenon, parental acute myeloid cell lines, HL-60… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 53 references

Antigen-activated human 3594 NANBAKHSH et al BLOOD, 5 JUNE 2014 x VOLUME 123

C Cerboni, A Zingoni, +3 authors A. Santoni
For personal use only. on June • 2014
View 1 Excerpt

Drug resistance: still a daunting challenge to the successful treatment of AML.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy • 2012
View 1 Excerpt

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