c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis.

  title={c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis.},
  author={Arash Nanbakhsh and C{\'e}cile Pochon and Aude Mallavialle and Sophie Amsellem and Jean Henri Bourhis and Salem Chouaib},
  volume={123 23},
Cytarabine (cytosine arabinoside) is one of the most effective drugs for the treatment of patients diagnosed with acute myeloid leukemia (AML). Despite its efficiency against AML cells, the emergence of drug resistance due to prolonged chemotherapy in most patients is still a major obstacle. Several studies have shown that drug resistance mechanisms alter the sensitivity of leukemia cells to immune system effector cells. To investigate this phenomenon, parental acute myeloid cell lines, HL-60… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 12 extracted citations

AML drug resistance: c-Myc comes into play.

View 6 Excerpts
Highly Influenced

Cellular immunotherapies for cancer.

Oncoimmunology • 2017
View 1 Excerpt

Donor-Derived Natural Killer Cell Infusion after Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplantation in Patients with Refractory Acute Leukemia.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation • 2016
View 1 Excerpt

Harnessing the immune system in acute myeloid leukaemia.

Critical reviews in oncology/hematology • 2016
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 53 references

Antigen-activated human 3594 NANBAKHSH et al BLOOD, 5 JUNE 2014 x VOLUME 123

C Cerboni, A Zingoni, +3 authors A. Santoni
For personal use only. on June • 2014
View 1 Excerpt

Drug resistance: still a daunting challenge to the successful treatment of AML.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy • 2012
View 1 Excerpt

Similar Papers

Loading similar papers…