c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis.

@article{Nieminen2007cMycPM,
  title={c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis.},
  author={Anni I Nieminen and Johanna I. Partanen and Annika Hau and Juha Klefstrom},
  journal={The EMBO journal},
  year={2007},
  volume={26 4},
  pages={1055-67}
}
Oncogenic c-Myc renders cells sensitive to TRAIL-induced apoptosis, and existing data suggest that c-Myc sensitizes cells to apoptosis by promoting activation of the mitochondrial apoptosis pathway. However, the molecular mechanisms linking the mitochondrial effects of c-Myc to the c-Myc-dependent sensitization to TRAIL have remained unresolved. Here, we show that TRAIL induces a weak activation of procaspase-8 but fails to activate mitochondrial proapoptotic effectors Bax and Bak, cytochrome c… CONTINUE READING