c-Myc mediates a hypoxia-induced decrease in acetylated histone H4.


Global acetylation of histone H4 is a mark of gene transcriptional activation. The c-Myc transcription factor binds to specific DNA sites in cellular chromatin and induces the acetylation of histone H4. In this study, hypoxia (1% Oxygen) induced a decrease in both global acetylated histone H4 (AcH4) and c-Myc in human lung carcinoma A549 cells and in human… (More)
DOI: 10.1016/j.biochi.2009.07.001


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