c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.

  title={c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.},
  author={Andrew P. Weng and John M Millholland and Yumi Yashiro-Ohtani and Marie Laure Arcangeli and Arthur Lau and Carol Wai and Cristina Del Bianco and Carlos G. Rodriguez and Hong Sai and John W Tobias and Yueming Li and Michael S Wolfe and Cathy Shachaf and Dean Felsher and Stephen C Blacklow and Warren S Pear and Jon C Aster},
  journal={Genes & development},
  volume={20 15},
Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and maintenance. Starting from an expression-profiling screen, we identified c-myc as a direct target of Notch1 in Notch-dependent T-ALL cell lines, in which Notch accounts for the majority of c-myc expression. In functional assays, inhibitors of c-myc interfere with the progrowth effects of activated Notch1, and enforced… CONTINUE READING
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Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.

Proceedings of the National Academy of Sciences of the United States of America • 2014
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