c-Myc functionally cooperates with Bax to induce apoptosis.

@article{Juin2002cMycFC,
  title={c-Myc functionally cooperates with Bax to induce apoptosis.},
  author={Philippe Juin and Abigail Hunt and Trevor D. Littlewood and Beatrice Griffiths and Lamorna Brown Swigart and Stanley Korsmeyer and Gerard Evan},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 17},
  pages={6158-69}
}
c-Myc promotes apoptosis by destabilizing mitochondrial integrity, leading to the release of proapoptotic effectors including holocytochrome c. Candidate mediators of c-Myc in this process are the proapoptotic members of the Bcl-2 family. We show here that fibroblasts lacking Bak remain susceptible to c-Myc-induced apoptosis whereas bax-deficient fibroblasts are resistant. However, despite this requirement for Bax, c-Myc activation exerts no detectable effects on Bax expression, localization… CONTINUE READING

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