c-Myc enhances protein synthesis and cell size during B lymphocyte development.

  title={c-Myc enhances protein synthesis and cell size during B lymphocyte development.},
  author={Brian M Iritani and Robert N. Eisenman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 23},
Members of the myc family of nuclear protooncogenes play roles in cell proliferation, differentiation, and apoptosis. Moreover, inappropriate expression of c-myc genes contributes to the development of many types of cancers, including B cell lymphomas in humans. Although Myc proteins have been shown to function as transcription factors, their immediate effects on the cell have not been well defined. Here we have utilized a murine model of lymphomagenesis (Emu-myc mice) to show that constitutive… CONTINUE READING


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