c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland

@article{Stoelzle2009cMycAM,
  title={c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland},
  author={Tina Stoelzle and Patrick Schwarb and Andreas Trumpp and Nancy E. Hynes},
  journal={BMC Biology},
  year={2009},
  volume={7},
  pages={63 - 63}
}
The oncoprotein c-Myc has been intensely studied in breast cancer and mouse mammary tumor models, but relatively little is known about the normal physiological role of c-Myc in the mammary gland. Here we investigated functions of c-Myc during mouse mammary gland development using a conditional knockout approach. Generation of c-myc fl/fl mice carrying the mammary gland-specific WAPiCre transgene resulted in c-Myc loss in alveolar epithelial cells starting in mid-pregnancy. Three major… CONTINUE READING