c-Myc Is Required for Maintenance of Glioma Cancer Stem Cells

  title={c-Myc Is Required for Maintenance of Glioma Cancer Stem Cells},
  author={Jialiang Wang and Hui Wang and Zhizhong Li and Qiulian Wu and Justin D Lathia and Roger E McLendon and Anita B. Hjelmeland and Jeremy Rich},
  journal={PLoS ONE},
  pages={1167 - 1174}
BACKGROUND Malignant gliomas rank among the most lethal cancers. Gliomas display a striking cellular heterogeneity with a hierarchy of differentiation states. Recent studies support the existence of cancer stem cells in gliomas that are functionally defined by their capacity for extensive self-renewal and formation of secondary tumors that phenocopy the original tumors. As the c-Myc oncoprotein has recognized roles in normal stem cell biology, we hypothesized that c-Myc may contribute to cancer… CONTINUE READING
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The cMyc target gene network

  • CV Dang, KA O’Donnell, KI Zeller, T Nguyen, RC Osthus
  • Semin Cancer Biol
  • 2006
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