c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain.

@article{Malaterre2008cMybIR,
  title={c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain.},
  author={Jordane Malaterre and Theo Mantamadiotis and Sebastian Dworkin and Sally Lightowler and Qing Yang and Mark I. Ransome and Ann M Turnley and Nancy R Nichols and Nikla R. Emambokus and Jon Frampton and R G Ramsay},
  journal={Stem cells},
  year={2008},
  volume={26 1},
  pages={173-81}
}
Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult… CONTINUE READING