c-Myb influences HIV type 1 gene expression and virus production.

  title={c-Myb influences HIV type 1 gene expression and virus production.},
  author={Melissa J. Churchill and R G Ramsay and David I Rhodes and Nicholas J. Deacon},
  journal={AIDS research and human retroviruses},
  volume={17 16},
c-Myb is expressed in proliferating T cells. Fifteen c-Myb-binding sites can be identified in the HIV-1 long terminal repeat (LTR), suggesting that c-Myb may regulate HIV-1 gene expression and virus replication. Increasing the cellular levels of c-Myb by transient transfection of CEM cells resulted in a 10- to 20-fold activation of HIV-1 LTR-driven gene expression and mutation of one high-affinity Myb-binding site within the LTR reduced this activation by 60 to 70%. Conversely, inhibition of c… CONTINUE READING