c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

@article{Cheng1999cMYCIW,
  title={c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function},
  author={S.-W. Grace Cheng and K. Davies and E. Yung and R. Beltr{\'a}n and Jin Yu and G. Kalpana},
  journal={Nature Genetics},
  year={1999},
  volume={22},
  pages={102-105}
}
Chromatin organization plays a key role in the regulation of gene expression. The evolutionarily conserved SWI/SNF complex is one of several multiprotein complexes that activate transcription by remodelling chromatin in an ATP-dependent manner. SWI2/SNF2 is an ATPase whose homologues, BRG1 and hBRM, mediate cell-cycle arrest; the SNF5 homologue, INI1/hSNF5, appears to be a tumour suppressor. A search for INI1-interacting proteins using the two-hybrid system led to the isolation of c-MYC, a… Expand
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