c-MYC: more than just a matter of life and death

@article{Pelengaris2002cMYCMT,
  title={c-MYC: more than just a matter of life and death},
  author={S. Pelengaris and M. Khan and G. Evan},
  journal={Nature Reviews Cancer},
  year={2002},
  volume={2},
  pages={764-776}
}
Deregulated expression of c-MYC occurs in a broad range of human cancers and is often associated with poor prognosis, indicating a key role for this oncogene in tumour progression. However, as established human tumours often bear multiple genetic lesions, it is difficult to determine whether c-MYC is instrumental in the initiation/progression of the tumour, or indeed whether inactivating c-MYC would lead to tumour regression. Regulatable transgenic mouse models of oncogenesis have shed light on… Expand
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