c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases.

@article{Takeuchi2003cMETEL,
  title={c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases.},
  author={Hiroya Takeuchi and Anton J. Bilchik and Sukamal Saha and Roderick R. Turner and David A. Wiese and Maki Tanaka and Christine T. Kuo and He-jing Wang and Dave S. B. Hoon},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2003},
  volume={9 4},
  pages={1480-8}
}
PURPOSE Both c-MET and vascular endothelial growth factor (VEGF)-C expression are important factors in primary carcinoma progression. We hypothesized that overexpression of c-MET and/or VEGF-C mRNA in primary colorectal cancer (CRC) can predict tumor invasion and regional metastasis. EXPERIMENTAL DESIGN The level of c-MET and VEGF-C mRNA expression was assessed using a quantitative RT-RealTime PCR assay on early stage primary CRC tumors (n = 36). RESULTS The c-MET mRNA copy number ranged… CONTINUE READING