c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma.

@article{Tokunou2001cMETEI,
  title={c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma.},
  author={Masahide Tokunou and T. Niki and Katsumi Eguchi and Sanae Iba and Hiroshi Tsuda and Tesshi Yamada and Yoshihiro Matsuno and Hisayoshi Kondo and Yukihito Saitoh and Hiroji Imamura and Setsuo Hirohashi},
  journal={The American journal of pathology},
  year={2001},
  volume={158 4},
  pages={1451-63}
}
Hepatocyte growth factor (HGF) plays important roles in tumor development and progression. It is currently thought that the main action of HGF is of a paracrine nature: HGF produced by mesenchymal cells acts on epithelial cells that express its receptor c-MET. In this investigation, we explored the significance of c-MET expression in myofibroblasts, both in culture and in patients with lung adenocarcinoma. We first showed that human myofibroblasts derived from primary lung cancer expressed c… CONTINUE READING

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