c-KIT codon 816 mutation in a recurrent and metastatic dysgerminoma of a 14-year-old girl: case study

@article{Pauls2004cKITC8,
  title={c-KIT codon 816 mutation in a recurrent and metastatic dysgerminoma of a 14-year-old girl: case study},
  author={Katharina Pauls and Eva Wardelmann and Sabine Merkelbach-Bruse and Reinhard Buettner and Hui Zhou},
  journal={Virchows Archiv},
  year={2004},
  volume={445},
  pages={651-654}
}
Dysgerminomas are rare female germ-cell tumors that correspond histologically and immunohistochemically to seminomas. Analogous to seminomas, most dysgerminomas respond very well to cisplatin- or carboplatin-based chemotherapy and to radiotherapy. KIT tyrosine kinase is crucial for normal germ-cell development, and its expression is observed in the majority of seminomas and dysgerminomas. Recently, activating KIT mutations were described in a panel of male germ-cell tumors [5, 10]. All… CONTINUE READING

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KIT mutations are common in testicular seminomas.

The American journal of pathology • 2004
View 8 Excerpts
Highly Influenced

Angiotensin-converting enzyme (CD143) in neoplastic germ cells.

Laboratory investigation; a journal of technical methods and pathology • 1999
View 1 Excerpt

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