c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1.

@article{Kardassis1999cJunTT,
  title={c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1.},
  author={Dimitris Kardassis and Paraskevi Papakosta and Katerina Pardali and Aristidis Moustakas},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 41},
  pages={29572-81}
}
The cell cycle inhibitor protein p21(WAF1/Cip1) (p21) is a critical downstream effector in p53-dependent mechanisms of growth control and p53-independent pathways of terminal differentiation. We have recently reported that the transforming growth factor-beta pathway-specific Smad3 and Smad4 proteins transactivate the human p21 promoter via a short proximal region, which contains multiple binding sites for the ubiquitous transcription factor Sp1. In the present study we show that the Sp1… CONTINUE READING

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