c-Jun protects hypoxia-inducible factor-1alpha from degradation via its oxygen-dependent degradation domain in a nontranscriptional manner.

@article{Yu2009cJunPH,
  title={c-Jun protects hypoxia-inducible factor-1alpha from degradation via its oxygen-dependent degradation domain in a nontranscriptional manner.},
  author={Bing Yu and Ze-Hong Miao and Yi Jiang and Mei-Hong Li and Na Yang and Ting Li and Jian Ding},
  journal={Cancer research},
  year={2009},
  volume={69 19},
  pages={7704-12}
}
Although hypoxia-inducible factor-1alpha (HIF-1alpha) has long been intensively investigated as a drug target by interfering with its expression or transcriptional function, the regulatory mechanisms of HIF-1alpha remain to be further clarified. We report here that c-Jun associates with HIF-1alpha via its oxygen-dependent degradation domain, masks the sites for ubiquitination, and thus protects HIF-1alpha from proteasome-executing degradation. All of these together resulted in the stabilization… CONTINUE READING

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