c-Jun and p53 activity is modulated by SUMO-1 modification.

@article{Muller2000cJunAP,
  title={c-Jun and p53 activity is modulated by SUMO-1 modification.},
  author={Sylviane Muller and Monika Berger and François Lehembre and Jacob S. Seeler and Ygal Haupt and Anne Dejean},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 18},
  pages={
          13321-9
        }
}
The ubiquitin-related SUMO-1 molecule has been shown recently to modify covalently a number of cellular proteins including IkappaBalpha. SUMO-1 modification was found to antagonize IkappaBalpha ubiquitination and protect it from degradation. Here we identify the transcription factors c-Jun and p53, two well known targets of ubiquitin, as new substrates for SUMO-1 both in vitro and in vivo. In contrast to ubiquitin, SUMO-1 preferentially targets a single lysine residue in c-Jun (Lys-229), and… CONTINUE READING
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