c-Jun NH2-terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled randomized study.

@article{Hussein2016cJunNK,
  title={c-Jun NH2-terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled randomized study.},
  author={Mostafa Hussein and Daniel C Chai and Cleophas Mutinda Kyama and Jason M. Mwenda and Stephen S. Palmer and J. B. Gotteland and Thomas D'hooghe},
  journal={Fertility and sterility},
  year={2016},
  volume={105 3},
  pages={815-824.e5}
}
OBJECTIVE To test the hypothesis that the c-Jun NH2-terminal kinase (JNK) inhibitor (JNKI) bentamapimod (AS602801/PGL5001) can reduce induced endometriosis in baboons. DESIGN Prospective randomized placebo-controlled study. SETTING Nonhuman primate research center. ANIMAL(S) Twenty baboons each underwent four laparoscopies. Initial screening laparoscopy (L1) was followed after one rest cycle by an endometriosis-induction laparoscopy (L2). Fifty days after L2, the baboons were randomized… CONTINUE READING