c-Jun NH2-terminal kinase activating kinase 1/mitogen-activated protein kinase kinase 4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation.

@article{Lotan2008cJunNK,
  title={c-Jun NH2-terminal kinase activating kinase 1/mitogen-activated protein kinase kinase 4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation.},
  author={Tamara L Lotan and Jonathan A. Hickson and Jeffrey S. Souris and Dezheng Huo and Jennifer Taylor and Terry Li and Kristen Otto and Seiko Diane Yamada and Kay Macleod and Carrie W. Rinker-Schaeffer},
  journal={Cancer research},
  year={2008},
  volume={68 7},
  pages={2166-75}
}
In many patients without clinical metastases, cancer cells have already escaped from the primary tumor and entered a distant organ. A long-standing question in metastasis research is why some disseminated cancer cells fail to complete steps of metastatic colonization for extended periods of time. Our laboratory identified c-Jun NH(2)-terminal kinase activating kinase 1/mitogen-activated protein kinase kinase 4 (JNKK1/MKK4) as a metastasis suppressor protein in a mouse xenograft model of… CONTINUE READING

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