c-Jun N-terminal kinase signaling pathway in excitotoxic cell death following kainic acid-induced status epilepticus.

@article{Spigolon2010cJunNK,
  title={c-Jun N-terminal kinase signaling pathway in excitotoxic cell death following kainic acid-induced status epilepticus.},
  author={Giada Spigolon and Carlo Andrea Veronesi and Christophe Bonny and Alessandro Vercelli},
  journal={The European journal of neuroscience},
  year={2010},
  volume={31 7},
  pages={1261-72}
}
Systemic injections of kainic acid (KA) cause epileptic seizures with delayed neuronal damage in the limbic system, particularly in the hippocampus. KA excitotoxicity activates complex signal transduction events that trigger apoptotic cell death. The c-Jun N-terminal kinase (JNK) pathway plays an important role in cell death, and the peptide D-JNKI1, a competitive JNK inhibitor, is a potent neuroprotective agent. To analyse the role of JNK and the effects of D-JNKI1 administration on… CONTINUE READING
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