c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies

@inproceedings{Rzeczkowski2011cJunNK,
  title={c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies},
  author={Katharina Rzeczkowski and Knut Beuerlein and Helmut M{\"u}ller and Oliver Dittrich-Breiholz and Heike W Schneider and Daniela Kettner-Buhrow and Helmut Holtmann and Michael Kracht},
  booktitle={The Journal of cell biology},
  year={2011}
}
Cytokines and stress-inducing stimuli signal through c-Jun N-terminal kinase (JNK) using a diverse and only partially defined set of downstream effectors. In this paper, the decapping complex subunit DCP1a was identified as a novel JNK target. JNK phosphorylated DCP1a at residue S315 in vivo and in vitro and coimmunoprecipitated and colocalized with DCP1a in processing bodies (P bodies). Sustained JNK activation by several different inducers led to DCP1a dispersion from P bodies, whereas IL-1… CONTINUE READING