c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.

Abstract

UNLABELLED Sustained c-Jun N-terminal kinase (JNK) activation has been implicated in many models of cell death and tissue injury. Phosphorylated JNK (p-JNK) interacts with the mitochondrial outer membrane SH3 homology associated BTK binding protein (Sab, or SH3BP5). Using knockdown or liver-specific deletion of Sab, we aimed to elucidate the consequences of… (More)
DOI: 10.1002/hep.28486

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@article{Win2016cJunNK, title={c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.}, author={Sanda Kyaw Win and Tin Aung Than and Robert Win Maw Min and Mariam Aghajan and Neil Kaplowitz}, journal={Hepatology}, year={2016}, volume={63 6}, pages={1987-2003} }