c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression.

@article{Gao2007cJunNK,
  title={c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression.},
  author={Feng-hou Gao and Qiong Wang and Yingli Wu and Xi Li and Ke-Wen Zhao and Guo-Qiang Chen},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={356 2},
  pages={505-11}
}
AML1-ETO fusion protein, a product of leukemia-related chromosomal translocation t(8;21), was reported to upregulate expression of connexin-43 (Cx43), a member of gap junction-constituted connexin family. However, its mechanism(s) remains unclear. By bioinformatic analysis, here we showed that there are two putative AML1-binding consensus sequences followed by two activated protein (AP)1 sites in the 5'-flanking region upstream to Cx43 gene. AML1-ETO could directly bind to these two AML1… CONTINUE READING

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