c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia

@article{Lagadinou2008cJunNK,
  title={c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia},
  author={Eleni D Lagadinou and Panos G. Ziros and Olga A Tsopra and Kostas Dimas and Dimitra Kokkinou and Eleni Thanopoulou and Marina Karakantza and Panayotis Pantazis and Alexandros Spyridonidis and Nicholas C. Zoumbos},
  journal={Leukemia},
  year={2008},
  volume={22},
  pages={1899-1908}
}
Chemotherapy resistance is a major challenge in acute myeloid leukemia (AML). Besides the P-glycoprotein efflux, additional cellular factors may contribute to drug resistance in AML. c-Jun N-terminal kinase (JNK) is activated after exposure of cells to chemotherapeutics. We asked whether chemoresistance in AML is attributed to intrinsic failure of the AML blasts to activate JNK. In vitro treatment of U937 AML cell line with anthracyclines induced a rapid and robust JNK phosphorylation and… CONTINUE READING

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