c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias.

@article{Yan2013cJunNK,
  title={c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias.},
  author={Jiajie Yan and Wei Kong and Qiang Zhang and Eric C Beyer and Gregory P. Walcott and Vladimir G. Fast and Xun Ru Ai},
  journal={Cardiovascular research},
  year={2013},
  volume={97 3},
  pages={589-97}
}
AIMS c-Jun N-terminal kinase (JNK) activation is implicated in cardiovascular diseases and ageing, which are linked to enhanced propensity to atrial fibrillation (AF). However, the contribution of JNK to AF remains unknown. Thus, we assessed the role of JNK in remodelling of gap junction connexin43 (Cx43) and development of AF. METHODS AND RESULTS AF induction, optical mapping, and biochemical assays were performed in young and aged New Zealand white rabbit left atria (LA) and cultured HL-1… CONTINUE READING
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