c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3.

@article{Velden2011cJunNK,
  title={c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3.},
  author={Jos L. J. van der Velden and John F Alcorn and Amy S. Guala and Elsbeth C H L Badura and Yvonne M. W. Janssen-Heininger},
  journal={American journal of respiratory cell and molecular biology},
  year={2011},
  volume={44 4},
  pages={571-81}
}
Transforming growth factor (TGF)-β1 is a key mediator of lung remodeling and fibrosis. Epithelial cells are both a source of and can respond to TGF-β1 with epithelial-to-mesenchymal transition (EMT). We recently determined that TGF-β1-induced EMT in lung epithelial cells requires the presence of c-Jun N-terminal kinase (JNK) 1. Because TGF-β1 signals via Smad complexes, the goal of the present study was to determine the impact of JNK1 on phosphorylation of Smad3 and Smad3-dependent… CONTINUE READING

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