c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104.

@article{Huang2012cJunNK,
  title={c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104.},
  author={Yi-Feng Huang and Jing-Jer Lin and C Lin and Yeu Su and S C Hung},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2012},
  volume={27 5},
  pages={1093-105}
}
Runx2 plays a crucial role in osteoblastic differentiation, which can be upregulated by bone morphogenetic proteins 2 (BMP2). Mitogen-activated protein kinase (MAPK) cascades, such as extracellular signal-regulated kinase (ERK) and p38, have been reported to be activated by BMP2 to increase Runx2 activity. The role of cjun-N-terminal kinase (JNK), the other kinase of MAPK, in osteoblastic differentiation has not been well elucidated. In this study, we first showed that JNK1 is activated by BMP2… CONTINUE READING