c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK.

@article{Matsuda2001cJunNK,
  title={c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK.},
  author={Shin-ichi Matsuda and Takashi Yasukawa and Yoshimi Homma and Yuko Ito and Takako Niikura and Takao Hiraki and Satoshi Hirai and Shigeo Ohno and Yoshiko Kita and Masaoki Kawasumi and Keisuke Kouyama and Takayuki Yamamoto and John M. Kyriakis and Ikuo Nishimoto},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 17},
  pages={6597-607}
}
Using a yeast two-hybrid method, we searched for amyloid precursor protein (APP)-interacting molecules by screening mouse and human brain libraries. In addition to known interacting proteins containing a phosphotyrosine-interaction-domain (PID)-Fe65, Fe65L, Fe65L2, X11, and mDab1, we identified, as a novel APP-interacting molecule, a PID-containing isoform of mouse JNK-interacting protein-1 (JIP-1b) and its human homolog IB1, the established scaffold proteins for JNK. The APP amino acids Tyr… CONTINUE READING