c-Fos proteins, induced by the serotonin receptor agonist DOI, are not expressed in 5-HT2A positive cortical neurons.

@article{Mckowiak1999cFosPI,
  title={c-Fos proteins, induced by the serotonin receptor agonist DOI, are not expressed in 5-HT2A positive cortical neurons.},
  author={Mariusz M{\'a}ckowiak and Agnieszka Chocyk and Katarzyna Fijał and Anna Czyrak and Krzysztof Wȩdzony},
  journal={Brain research. Molecular brain research},
  year={1999},
  volume={71 2},
  pages={
          358-63
        }
}
In the present study, we tried to find out whether the expression of c-Fos proteins induced by DOI, an agonist of 5-HT2A/2C receptor subtypes is colocalized with 5-HT2A receptor protein in cortical neurons. 5-HT2A receptor protein was found in two major neuronal elements: dendritic processes (seen in layers II/III-V) and less abundantly in cell bodies (layer V). In our experiment, DOI (8 mg/kg) induced a robust appearance of c-Fos proteins mainly in neuronal nuclei of the upper part of layer V… CONTINUE READING

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